European Diabetes Research Programme in Cellular Plasticity Underlying the Pathophysiology of Type 2 Diabetes supported by a research grant from AstraZeneca
Request for Applications
Deadline for submission of applications: 1 November 2015
The European Foundation for the Study of Diabetes (EFSD) was created by the European Association for the Study of Diabetes (EASD) to provide multiple funding initiatives in all areas of diabetes research. The aims of EFSD are to encourage and support research in the field of diabetes, to rapidly diffuse acquired knowledge and to facilitate its application.
AstraZeneca is a global pharmaceutical organisation commited to innovative solutions that support patients, physicians and healthcare systems to address the global burden of diabetes.
Programme and Research Focus
EFSD has established this European Diabetes Research Programme in Cellular Plasticity Underlaying the Pathophysiology of Type 2 Diabetes to stimulate and accelerate European research and encourage projects aimed at advancing current knowledge in this field. To achieve the goals and objectives of this Programme, EFSD invite applications by issuing this "Request for Applications" (RFA), which indicates joint funding as well as areas of research emphasis.
While it is recognised that type 2 diabetes is the consequence of inadequate beta cell function in the face of insulin resistance, the underlying molecular defects remain elusive. Recent results have implicated cellular plasticity in the disease process, with partial or complete dedifferentiation of beta cells and insulin target cells. A more complete understanding of such cellular plasticity in type 2 diabetes and the potential for its reversibility may lead to the development of a novel therapy.
Particularly welcome are projects studying the effect of GLP-1 and DPP4 inhibition on cellular plasticity and recovery of beta cell function.
Mechanism of Support and Review
Research will be supported through the award of grants, each of up to Euro 100,000, payable in the first year and in one instalment. The duration of each award may be one year or longer, depending upon the needs of the project and as justified in the application. EFSD may, on advisement from the Review Committee, recommend an award in a lin a different amount from that requested, but which is considered more appropriate for the proposed studies.
Studies forming part of a larger project wil be considered for funding but this will need to be well justified in the application (see Review Considerations).
Applications for an EFSD research grant are invited from single non-profit institutions or groups of such institutions from Europe and associated countries. The principal investigator and any co-investigators must be employed full-time at a non-profit institution and the study must be performed at their place of work.
Applications will be subject to scientific review by a specialised ad hoc committee. It is anticipated that applications will be received, reviewed and approved for funding by February 2016.
Prior to any final decision on funding, and in order to offer applicants the opportunity to benefit from the review process, EFSD reserves the right to request revision to applications in accordance with the recommendations of the Review Committee.
Research Grant Applications
Applications for research grants may be subjected to pre-review (or triage) procedures. In this event, any application rejected at pre-review will not be subject to a complete scientific review.
The deadline for receipt of research grant applications for funding this year 1 November 2015.
All budgets are to be prepared in Euro. For countries in which the Euro is not yet the common currency, the exchange rate (between the Euro and the local currency in the country where the work is to be performed) used for calculating the Euro budget must be mentioned under "Budget Justification".
All applications must be prepared on the official application form and completed in strict accordance with the detailed instructions to be found on these forms. Applications which do not comply with the instructions given in the application form will not be considered for review.
Completed applications will be evaluated in accordance with the criteria stated below for scientific/technical merit by an appropriate scientific committee.
Review criteria are as follows:
- Significance: Does the study address an important problem in keeping with the goals and focus areas of this Programme? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of the proposed studies on the concepts or methods that drive this field?
- Approach: Are the conceptual framework, design, methods and analyses adequately developed, well integrated, and appropriate to the aims of the project? Are they supported by preliminary data? Does the applicant acknowledge potential problem areas and consider alternative tactics?
- Innovation: Does the project employ novel concepts, approaches or methods? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies?
- Investigator: Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers, if any?
- Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support?
- Budget: and feasilibility: Is the requested budget appropriate for the proposed study? Is the requested duration suitable for completion of the project?
- Contribution towards a larger research project: Is the work described in the application intended as part of a larger project? If so, is there any overlap? Is there a clear explanation how the new work will contribute towards the overall success of that larger project?
Reporting Requirements and Approval of Funding
All investigators funded by this Programme are required to submit a scientific progress report at the end of the project period. For those projects where funding is distributed over a period of more than one year, interim progress reports will also be required. Such reports will be subject to assessment prior to the release of any further funds.
Investigators must provide EFSD with copies of papers accepted for publication, and must acknowledge the support of the Programme in all written material by use of the phrase: "funded by an EFSD research grant supported by AstraZeneca".
Applications for a grant renewal will be accepted on a competitive basis, with the same review process as described in this Announcement. Such applications will thus be considered in the same fashion as all other new applications received for review and without any special priority.
|Application Deadline:||1 November 2015|
|Anticipated Award:||February 2016|
European Foundation for the Study of Diabetes
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40591 Düsseldorf, Germany
Tel: +49-211-75 84 69 0
Fax: + 49-211-75 84 69 29